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Suvexx™ – a new combination product for acute migraine treatment

What is Suvexx?

Suvexx is a combination of two commonly used acute Migraine

<span style="font-weight: 400;">A migraine is a powerful headache that often happens with nausea, vomiting, and sensitivity to light. Migraines can last from 4 hours to 3 days, and sometimes longer.Most people start having migraine headaches between ages 10 and 40. But many women find that their migraines improve or disappear after age 50.</span><i><span style="font-weight: 400;">Référence : webmd.com, </span></i><i><span style="font-weight: 400;">https://www.webmd.com/migraines-headaches/migraines-headaches-migraines#1</span></i><i><span style="font-weight: 400;">  consulted on july 4</span></i><i><span style="font-weight: 400;">th</span></i><i><span style="font-weight: 400;">,2019.</span></i>
" >migraine [1] medications in a single tablet: sumatriptan [2] 85 mg and naproxen sodium 500 mg. This product has been available in the U.S. for many years under the brand name Treximet.

Combining a triptan and an anti-inflammatory [3] (NSAID) is a common approach for migraines that won’t be successfully controlled by one medication alone. See here to read more about combinations (see this post [4]). 

The recommended dose is 1 tablet of Suvexx taken at the start of migraine pain. The maximum dosage is 2 tablets per 24 hours, taken at least 2 hours apart. This medication may be taken with or without food and should not be split, crushed, or chewed.

Does Suvexx work to treat migraine attacks? 

Because Suvexx contains two medications that work differently to treat migraine, some people may find it more effective than using a triptan or NSAID alone. 

A large analysis of studies evaluating the combination of sumatriptan plus naproxen found that 58% of people with moderate or severe attacks reported significant pain reduction or relief after 2 hours with the combination of sumatriptan and naproxen, compared to 52% with sumatriptan alone, 44% with naproxen alone and 27% with placebo. 

The combination of sumatriptan and naproxen was also more effective in treating other migraine symptoms (nausea, sensitivity to light or sound) and allowing return of function. 

Are there side effects or contra-indications to Suvexx?

Side effects [5] can relate to sumatriptan or naproxen and may include: Dizziness

<span style="font-weight: 400;">Dizziness is a term used to describe a range of sensations, such as feeling faint, woozy, weak or unsteady. Dizziness that creates the false sense that you or your surroundings are spinning or moving is called vertigo.</span><i><span style="font-weight: 400;">Reference : By Mayo Clinic Staff,</span></i> <i><span style="font-weight: 400;">https://www.mayoclinic.org/diseases-conditions/dizziness/symptoms-causes/syc-20371787</span></i><i><span style="font-weight: 400;"> , </span></i><span style="font-weight: 400;">july 1</span><span style="font-weight: 400;">st</span><span style="font-weight: 400;">,2019</span>
" >dizziness [6], sleepiness, nausea, indigestion, dry mouth, tingling or burning of the skin and chest discomfort. 

Suvexx has the same restrictions and risks as Triptans

<span style="font-weight: 400;">Triptans are a family of tryptamine-based drugs used as abortive medication in the treatment of migraines and cluster headaches.</span><span style="font-weight: 400;"> </span><i><span style="font-weight: 400;">Reference: Wikipedia,</span></i> <i><span style="font-weight: 400;">https://en.wikipedia.org/wiki/Triptan</span></i><i><span style="font-weight: 400;"> , consulted on july 08</span></i><i><span style="font-weight: 400;">th</span></i><i><span style="font-weight: 400;">,2019.</span></i>
" >triptans [7] and NSAIDs and should not be used in the following situations (read more HERE [8])

What could be the pros and cons of this new option? 

PROS: For people who already use or are considering combination therapy to increase effectiveness of acute migraine treatments, Suvexx offers the convenience of taking just one tablet at migraine onset.

CONS: Possible downsides include a higher cost than sumatriptan or naproxen purchased individually and lack of dosing flexibility as only one tablet strength is available. 


Law S, Derry S, Moore RA. Sumatriptan [2] plus naproxen for the treatment of acute migraine attacks in adults. Cochrane Database of Systematic Reviews 2016, Issue 4. Art. No.: CD008541. DOI: 10.1002/14651858.CD008541.pub3.

Product Monograph [Suvexx]. Health Canada Drug product database. Available from: https://health-products.canada.ca/dpd-bdpp/info.do?lang=en&code=98619 [10]. Accessed online Sept 29, 2020. 

Brandes JL, Kudrow D, Stark SR, et al. Sumatriptan-naproxen for acute treatment of migraine: a randomized trial. JAMA. 2007 Apr 4;297(13):1443-54. doi: 10.1001/jama.297.13.1443.