Different nutraceuticals and supplements have been studied for migraine  prevention. These products are often perceived as safer and «more natural». Overall, supplements are active substances and should be managed exactly like medications.
A few comments can be made on supplements.
- There are multiple brands of supplements. It’s important to verify that the correct dose is used. The number of pills, capsules, grams of powder etc required may vary.
- For magnesium , different kinds exist and some forms (like oxide) are not proven for migraine prevention. Citrate and glycinate are preferred.
- As the doses used for prevention are quite high, it’s not very helpful to try to get these nutraceuticals through diet only.
- Supplements are often well tolerated, but still may have side effects .
- Supplements are not necessarily safe during pregnancy, you should discuss with your health care provider
- The cost of supplements can be high, and they are not covered by many drug plans
- If a supplement works to prevent your migraines, it should not be stopped abruptly as it can lead to a deterioration.
Table: Overview of nutraceuticals used for migraine prevention
(may be divided in separate doses)
|Mechanism||Side effects |
Citrate or glycinate
|600 mg/day||Stabilizes neuronal membrane Plays a role in energy metabolism||Diarrhea|
|400 mg/day||Plays a role in energy metabolism||Makes urine darker yellow|
|Coenzyme Q10||300 mg / day||Plays a role in energy metabolism|
|150 mg/day||Action on TRPA1 channels, proteins that are receptive to oxidative stress ||Stomach upset and burping |
Concerns of liver toxicity, not used anymore
|Action on TRPA1 channels, proteins that are receptive to oxidative stress||May interact with medications like Coumadin|
Some brands (Migravent, Migrelief, many others) propose combinations of supplements, sometimes with other products for which there is not much evidence. Any trial should be done the way you would test a medication, with a diary, so you can make a decision based on facts.
Rajapakse T, Pringsheim T. Nutraceuticals in Migraine : A Summary of Existing Guidelines for Use. Headache. 2016;56(4):808-16.
Orr SL. Diet and nutraceutical  interventions for headache management: A review of the evidence. Cephalalgia. 2016;36(12):1112-33.