Feverfew, also known as wild chamomile, has been traditionally used in the treatment of headache and migraine. Since clinical trials have confirmed its effectiveness against headaches and migraine. Feverfew is recommended as a migraine prophylactic. The most well-studied and abundant group of active compounds in feverfew are the sesquiterpene lactones produced by superficial leaf glands, with Parthenolide considered to be the main active ingredient. Parthenolide can also be found in other Asteraceae species, such as German Chamomile.

Reference: by Snezana Agatonovic-Kustrin, https://www.omicsonline.org/open-access/migraine-headaches-feverfew-or-chamomile-leaves-2329-6798-1000169.php?aid=65428 , july 2nd,2019