Migraine can significantly impact daily life, leading many to seek effective migraine prevention methods. Natural supplements and nutraceuticals are increasingly popular for managing migraine, often perceived as safer alternatives to traditional medications. This article explores various natural supplements, their mechanisms, dosages, and potential side effects to provide a comprehensive guide for those considering these options. However, it’s important to recognize that these supplements are active substances and should be approached with similar caution as pharmaceuticals. As with any treatment, we recommend you speak with your healthcare provider before starting or stopping any supplements for migraine prevention.
Key Considerations for Supplements
- Variability in Brands: Different brands may vary in dosage forms (pills, capsules, powder grams). Ensuring correct dosage is crucial for effectiveness.
- Types of Magnesium: Citrate and glycinate are preferred over oxide for migraine prevention due to better absorption and efficacy.
- Pregnancy Considerations: Not all supplements are safe during pregnancy; consult with healthcare providers before use.
- Cost and Coverage: Supplements can be expensive and may not be covered by insurance plans.
- Abrupt Cessation: Discontinuing effective supplements suddenly can lead to worsening symptoms; gradual tapering is recommended.
Overview of Nutraceuticals Used for Migraine Prevention
* Recommended by the Canadian Headache Society Guidelines
Some brands (Migravent, Migrelief, many others) propose combinations of supplements, sometimes with other products for which there is not much evidence. Any trial should be done the way you would test a medication, with a diary, so you can make a decision based on facts.
Trusting the Content of Vitamins and Supplements
Complementary and integrative medicine is a key focus for migraine treatment. Minerals and supplements like Magnesium, Riboflavin, and Coenzyme Q10 (supported by Grade B, C evidence) may aid in migraine prevention, as recommended by doctors. However, selecting the right supplement amidst various brands and formulations can be challenging

Supplements can vary in quality and safety. Look for one of the above symbols on the bottle to determine whether the product has been third-party tested, which can help guide your choice. Similarly, the ConsumerLab.com website offers valuable information on supplements that can assist in making informed choices.
For more information on selecting supplements for migraine, see this post or watch our webinar on supplements for migraine.
References
- Gazerani P, et al. A randomized, double-blinded, placebo-controlled trial of vitamin D3 supplementation in adult patients with migraine. Curr Med Res Opin. 2019;35(4):715-723.
- Rajapakse T, Pringsheim T. Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use. Headache. 2016;56(4):808-816.
- Orr SL. Diet and nutraceutical interventions for headache management: A review of the evidence. Cephalalgia. 2016;36(12):1112-1133.
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