Topiramate (Topamax) is an antiepileptic drug recently approved by the U.S. Food and Drug Administration (FDA) for prevention of migraine headache in adults. Its exact mechanism of action is uncertain, but it is known to affect neuronal hyperexcitability,1 which is one probable factor in the development of migraine.

Reference:  by JANE HUNTINGTON, M.D., and CARRIE L. YUAN, PHARM. D., https://www.aafp.org/afp/2005/1015/p1563.html ,consulted on july 08th,2019